Serology demonstrated that pigs vaccinated with either regimen of Fostera Gold PCV MH or the other vaccine developed antibodies against PCV2, as expected, Bandrick noted. 'The strength of the PCV2-specific, IFN-γ response correlates with protective immunity,' she said. The assay detected the number of lymphocytes isolated from blood that responded to the vaccines by secreting the cytokine interferon gamma (IFN-γ) when exposed to PCV2 antigen. 4Ĭell-mediated immunity was evaluated with an enzyme-linked immunosorbent spot assay. The new vaccine's duration of immunity against PCV2 is 23 weeks, she said, and noted that the vaccine's duration of immunity against M. Meggan Bandrick, DVM, PhD, senior manager, Global Biologics Research, Zoetis, explained that 'a higher T cell response after vaccination is associated with a longer duration of immunity, 3 which is especially important with persistent viruses like PCV2.'

'In contrast, Circumvent PCV-M G2 induced very little detectable cell-mediated immunity,' she reported.

'Pigs in both groups vaccinated with Fostera Gold PCV MH had a higher T cell response than pigs vaccinated with Circumvent PCV-M G2 (Figure 1),' said Maria Cristina Venegas Vargas, DVM, PhD, manager, Global Biologics Research, Zoetis. Three weeks after the last vaccination was administered, pigs were challenged with virulent PCV2d because it's the most prevalent PCV2 genotype in US herds. Controls: 1 ml saline at 3 and 6 weeks of age.Circumvent® PCV-M G2 split dose: 1 ml at 3 and 6 weeks of age.Fostera Gold PCV MH one dose: 2 ml at 3 weeks of age.

Fostera Gold PCV MH split dose: 1 ml at 3 and 6 weeks of age.They compared results to those from pigs given another commercial PCV2 vaccine and to control pigs that received only saline. Zoetis researchers evaluated cell-mediated immunity in pigs vaccinated with Fostera® Gold PCV MH, 1 the new vaccine that protects against Mycoplasma hyopneumoniae (M. A new porcine circovirus type 2 (PCV2) vaccine from Zoetis produces a robust and lasting cell-mediated immune response - the type of response that's essential for protecting pigs against PCV2 disease.

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